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By Lily McCann < Back to Issue 3 Belly bugs: the aliens that live in our gut By Lily McCann 10 September 2022 Edited by Andrew Lim and Zhiyou Low Illustrated by Helena Pantsis Next Figure 1 (1): "Animalcules" The figures above may look exceedingly simple to you. Beautifully drawn, yes, but nothing particularly complicated —mere ovals and lines of black ink. If I told you that the drawings were 350 years old, your interest might be piqued by that fascination we hold for all historical relics. You might wonder what the images are attempting to portray. You would only be more confused, however, were I to describe them to you using the name they were known by to the artist: “animalcules”. (2) These drawings, penned by a Dutch draughtsman in the early 1680s, are the first known depictions of bacteria from inside a human body (2). They were discovered by a man called Anthonie van Leeuwenhoek in a sample taken from between his teeth. Leeuwenhoek had examined “animalcules” in various water samples before turning to saliva, analysing the shape and movements of the little cells beneath his microscope, which he made from hand-crafted glass mounted between plates of brass. It is now known that these “animalcules” are in fact bacteria, and that they are avid colonisers not only of our mouths but every other body surface, too. These single-celled organisms parted ways with animals some 2.7 billion years ago in evolution and could not appear any more alien to ourselves (3). Though simple in structure and function, they are capable of populating the most inhospitable and extraterrestrial of environments. In fact, Deinococcus radiodurans (pictured below) can survive for years in the harsh vacuum of space (4). Figure 2 (5): Deinococcus radiodurans Freaky, right? The evolutionary distance between bacteria and ourselves does not seem to deter them from entering into the most intimate of symbiotic relationships with us. Despite their alien-ness, despite billions of years of divergent evolution, we have not lost the ability to communicate with these distant relatives of ours. In fact, communication with bacteria is a daily and essential part of our lives. The reason we can still chat with these creatures is that they are made up of the same basic “stuff” that we are: genetic material made of sugars, phosphates and nitrogen bases to dictate our functions; proteins to carry out our cellular processes; membranes to hold us together. All these aspects form a common basis for language. Just as human languages consist of orally transmitted units of sounds that can be translated and understood, bacteria can impart signals in the form of particles that can be decoded and acted upon by our own cells. One example of this kind of dialogue is the production of molecules called short chain fatty acids by bacteria that digest plant materials in our gut. These bacteria impart their gratitude to us for supplying them with suitable foods by releasing short chain fatty acids, which in turn tell our gut not to worry, signalling our cells and instructing them to reduce inflammation, build up our gut wall and even help fix our blood pressure. These molecules can also travel to the brain, where they are thought to influence the release of various signals including that of the “feel-good” hormone serotonin. (6) There’s a whole world of dialogue beyond this often referred to as the gut-brain axis of health. Research into the area has revealed that signals produced by gut bacteria are extremely influential in a number of conditions including anxiety and Parkinson’s disease. These relationships often work both ways, giving rise to a strange “chicken-and-egg” situation: those who demonstrate symptoms of such conditions are found to carry altered gut bacterial populations, and altering gut bacteria can in turn change symptoms. For example, in a cruel experiment involving the separation of infant monkeys from their mothers, the stress caused by separation changed the distribution of bacteria colonies in the infants’ guts, whilst administering a certain bacteria often imparted to infants by their mothers was found to reverse the symptoms of this stress (7). The way that bacteria can change our very emotions has significant implications for our idea of personhood. What are we, if how we act depends on the alien cells we carry in our digestive tracts? Perhaps we ought to extend our definition of identity to include these little cells that are truly, it seems, a part of how we are—another organ of our body, even. Happily (for those of you who support the philosophy of a ‘growth mindset’), the way our gut influences our minds is subject to manipulation. And we do not need a scientist to isolate and administer a certain bacterial species to us in order to change it; evidence suggests that simply altering what we eat can have a profound influence. Dietary change is known to directly alter bacterial gut colonies, and the change shown to bring about the most harmonious of conversations with our gut is increasing our intake of dietary fibre. Flooding our gut community with plentiful fibre causes a rush of signals from bacteria that promote gut health, mental health and healthy ageing. In contrast, a low fibre diet can promote diabetes, cardiovascular problems and, for pregnant mothers, may compromise the neural functioning of a developing child (8). What does this mean for medicine? Can we harness the billion-year old dialogue between our cells and the aliens that colonise our gut for our own benefit? Can we coax these residents into a mutually beneficial relationship by approaching them in the right tone? These questions are gradually gaining popularity among the scientific community as trials of probiotic administration are explored in the context of treating illnesses from depression to gastrointestinal disorders (9). We are yet to see where such studies will lead us. When the outside world seems increasingly bleak, I find comfort in the fact that within us rumbles on the activity of an intricate and disinterested universe, completely alien to and yet an integral part of ourselves. Like farmers of a garden in times of shortage, we exist in a state of codependency with the world we nurture inside our bodies. If we foster a good relationship with its inhabitants, they can protect us from the afflictions of illness, sadness and madness that threaten our species day by day. References : 1. The Royal Society. Bacteria from Leeuwenhoek's mouth [Internet]. 2022 [cited 17 March 2022]. Available from: https://royalsocietypublishing.org/cms/asset/2bf20f9f-28e1-4126-bd7e-f92950899a2b/rstb20140344f03.jpg 2. Lane N. The unseen world: reflections on Leeuwenhoek (1677) ‘Concerning little animals’ | Philosophical Transactions of the Royal Society B: Biological Sciences [Internet]. Philosophical Transactions of the Royal Society B: Biological Sciences. 2022 [cited 17 April 2022]. Available from: https://royalsocietypublishing.org/doi/10.1098/rstb.2014.0344 3. Cooper G. The Origin and Evolution of Cells [Internet]. Ncbi.nlm.nih.gov. 2022 [cited 17 April 2022]. Available from: https://www.ncbi.nlm.nih.gov/books/NBK9841/#:~:text=The%20eukaryotes%20developed%20at%20least,is%20from%20present%2Dday%20eukaryotes 4. Cox M, Battista J. Deinococcus radiodurans — the consummate survivor. Nature Reviews Microbiology. 2005;3(11):882-892. 5. 5. The European Synchroton. Deinococcus radiodurans [Internet]. 2022 [cited 5 May 2022]. Available from: https://www.esrf.fr/UsersAndScience/Experiments/MX/Research_and_Development/Biology/Deinococcus_radiodurans 6. De Angelis M, Piccolo M, Vannini L, Siragusa S, De Giacomo A, Serrazzanetti D et al. Fecal Microbiota and Metabolome of Children with Autism and Pervasive Developmental Disorder Not Otherwise Specified. PLoS ONE. 2013;8(10):e76993. 7. Bailey M, Coe C. Maternal separation disrupts the integrity of the intestinal microflora in infant rhesus monkeys. Developmental Psychobiology. 1999;35(2):146-155. 8. Buffington S, Di Prisco G, Auchtung T, Ajami N, Petrosino J, Costa-Mattioli M. Microbial Reconstitution Reverses Maternal Diet-Induced Social and Synaptic Deficits in Offspring. Cell. 2016;165(7):1762-1775. 9. Kazemi A, Noorbala A, Azam K, Eskandari M, Djafarian K. Effect of probiotic and prebiotic vs placebo on psychological outcomes in patients with major depressive disorder: A randomized clinical trial. Clinical Nutrition. 2019;38(2):522-528. 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By Rachel Ko < Back to Issue 3 “Blink and you’ll miss it”: A Third Eyelid? By Rachel Ko 10 September 2022 Edited by Ashleigh Hallinan and Yvette Marris Rachel Ko Next The creature snarls a deep, thundering growl, tensing its protruding muscles that are covered in layers of thick, green, armour-like scales, individually rattling by the sheer force of its stance. Clenching its claws, the lizard glares with a bizarrely human expression, a villain trapped in a peculiar hybrid humanoid form. As the screams of terrified students fill the air, the camera zooms into the mutant’s glistening yellow eye, and it blinks; a slimy, translucent covering flickers across its eyeball, leaving a trail of moisture - grotesque proof of its reptilian form. A charm of the cinematic world is that aliens, radioactive spider superheroes and giant mutant lizards can exist in the same universe as the regular person. On a recent movie night, watching The Amazing Spiderman, the villain Lizard caught my eye. The creature is a metamorphosed version of human scientist Dr Curt Connors, who had attempted cross-species genetic regeneration on himself. Largely CGI, the Lizard’s primitive no-frills characterisation makes him an unconventional superhero antagonist. However, upon focus, these exaggerated reptilian characteristics are wha become staples of the Lizard’s uniquely villainous appeal: the alien-green colouring, the razor-sharp claws, the terrifying teeth and, of course, the glistening yellow eyes. Figure 1: Spiderman's 'The Lizard' In reference to the creation of these eerie eyeballs, animation supervisor David Schaub confirmed the purposeful inclusion of a nictitating membrane (1). This membrane is a slimy skin-like covering more commonly known as the Third Eyelid. In animals such as birds, reptiles, fish, amphibians, and some mammals (2), it acts as a bizarre protective mechanism that maintains moisture while retaining vision (3) - and also gives the Lizard’s glare that extra kick. Acting like a windscreen wiper, the membrane ‘nictitates’, meaning it blinks, to keep debris and dust out of the eye while simultaneously hydrating it. Its transparency also allows vision underground or underwater (4). Figure 2: A bird blinking! There is just one primate species known to have a prominent nictitating membrane: the Calabar angwantibo, also known as the golden potto, which is a rare African prosimian primate found only in Cameroon and Nigeria (5). Figure 3: Look at the Calabar's nictating membrane! The membrane is a major characterising feature of The Amazing Spiderman’s creepy mutant reptilian aura. However, this Third Eyelid actually has a homologous counterpart in Dr Connors’ eyes too. In fact, it is found in all humans, and is known as our plica semilunaris, a vertical fold of conjunctiva in the inner corner of the eye (6). Although it plays a minor role in eye movement and tear drainage (7), the plica semilunaris has nowhere near as great a function in humans as the nictitating membrane does in animals (8). The plica semilunaris and its associated muscles are merely an evolutionary remnant of the nictitating membrane that existed in our reptilian ancestors millions of years ago (9). Evolution is driven by selective advantage: the traits that allow organisms to survive and reproduce are the ones that are selected for and thrive within the population, passed down from one generation to the next (10). Traits that are disadvantageous to organisms decrease their chance of survival and reproduction, meaning fewer offspring will inherit the trait, causing it to eventually disappear from the population (11). The mystery remains as to why human ancestors lost the nictitating membrane in the first place, but it is likely that changes in habitat and lifestyle regarding eye physiology made it selectively advantageous to lose the Third Eyelid, rather than wasting precious energy on maintaining a no-longer-vital mechanism (12). For some reason, though, once the nictitating membrane had evolved into nothing more than a miniscule pink fold in the corner of the eye, it still persisted. Some argue that this is because humans have had no evolutionary incentive to completely lose them (13) – the plica semilunaris is just harmless enough that it has flown under the radar of evolution’s cut. Having suggested that, however, the primary clinical significance of the plica semilunaris has been connected to allergies of the eye, in which release of inflammatory molecules like histamine causes the tissue to become swollen and itchy (14). Thus, it is worth considering another argument: that the persistence of the plica semilunaris may be indicative of some beneficial function, particularly in its role in human eye protection. It has been found that the tissue observed in early intrauterine (within the uterus) development has a dense infiltration of immune cells like macrophages and granulocytes that serve to engulf and destroy foreign invaders of the tissue (15). Along with the abundance of blood vessels and immune chemical signalling, this has suggested a specialised role in eye protection, a benefit that may have very well ensured the plica semilunaris’ survival within human populations until this day (16). One fascinating clinical case, which showcases the outlandish capabilities of this vestigial feature, is of a child for whom it was not a question of why the plica semilunaris persisted, but an actual nictitating membrane. This peculiar instance was presented on a 9 year-old girl whose left eye had a non-progressive translucent membrane covering it horizontally. The globe of the eye was able to move freely beneath the membrane, suggesting that there was no attachment. However, it was causing amblyopia (also known as a lazy eye), and poor vision, so the nictitating membrane was successfully removed by simple excision (17). Figure 4: The plica semilunaris Figure 5: A clinical case of a human nictating membrane The only other recorded case of persisting nictitating membrane was an infant boy born prematurely with Edwards syndrome, who had nictitating membranes in both eyes (18). However, due to the baby’s infancy and condition, membrane imaging was unobtainable. Thus, arguably, the most striking aspect of the 9 year-old girl’s case was the pre-procedure imaging of her eye: an intriguing, almost alien-like fusion of the human eye and that of our reptilian ancestors. This case study can be interpreted as an exaggerated example of an existing link between the nictitating membranes we see in animals today, and the plica semilunaris that exists, tucked away, in the corner of our very own eyes. So, next time you find yourself staring into your partner’s baby blues, or putting on eyeliner in the mirror, keep an eye out for this fascinating evolutionary remnant; but be quick because - blink and you’ll miss it. References Sarto D. 'Spider-Man'’s Lizard Part 1: The Animation [Internet]. Animation World Network. 2012 [cited 4 May 2022]. Available from: https://www.awn.com/vfxworld/spider-mans-lizard-part-1-animation Butler A, Hodos W. Comparative vertebrate neuroanatomy. Hoboken (New Jersey): Wiley-Interscience; 2005. Why do cats have an inner eyelid as well as outer ones? [Internet]. Scientific American. 2006 [cited 4 May 2022]. Available from: https://www.scientificamerican.com/article/why-do-cats-have-an-inner/ The Equine Manual [Internet]. Elsevier; 2006. Available from: http://dx.doi.org/10.1016/B978-0-7020-2769-7.X5001-1 Montagna W, Machida H, Perkins EM. The skin of primates. XXXIII. The skin of the angwantibo (Arctocebus calabarensis) [Internet]. Vol. 25, American Journal of Physical Anthropology. Wiley; 1966. p. 277–90. Available from: http://dx.doi.org/10.1002/ajpa.1330250307 Plica semilunaris [Internet]. Merriam-Webster.com medical dictionary. [cited 4 May 2022]. Available from: https://www.merriam-webster.com/medical/plica%20semilunaris LaFee S. Body and Whole [Internet]. UC Health - UC San Diego. 2016 [cited 4 May 2022]. Available from: https://health.ucsd.edu/news/features/pages/2016-06-30-listicle-body-and-whole.aspx Dartt D. Foundation Volume2, Chapter 2. The Conjunctiva–Structure and Function [Internet]. Oculist.net. 2006 [cited 4 May 2022]. Available from: http://www.oculist.net/downaton502/prof/ebook/duanes/pages/v8/v8c002.html Gonzalez R. 10 Vestigial Traits You Didn't Know You Had [Internet]. Gizmodo. 2011 [cited 4 May 2022]. Available from: https://gizmodo.com/10-vestigial-traits-you-didnt-know-you-had-5829687 Sukhodolets V. V. (1986). K voprosu o roli estestvennogo otbora v évoliutsii [The role of natural selection in evolution]. Genetika, 22(2), 181–193. Sukhodolets V. V. (1986). K voprosu o roli estestvennogo otbora v évoliutsii [The role of natural selection in evolution]. Genetika, 22(2), 181–193. Gonzalez R. 10 Vestigial Traits You Didn't Know You Had [Internet]. Gizmodo. 2011 [cited 4 May 2022]. Available from: https://gizmodo.com/10-vestigial-traits-you-didnt-know-you-had-5829687 Kotecki P, Olito F. We No Longer Need These 9 Body Parts [Internet]. ScienceAlert. 2019 [cited 4 May 2022]. Available from: https://www.sciencealert.com/we-no-longer-need-these-9-body-parts Bielory L, Friedlaender MH. Allergic Conjunctivitis [Internet]. Vol. 28, Immunology and Allergy Clinics of North America. Elsevier BV; 2008. p. 43–58. Available from: http://dx.doi.org/10.1016/j.iac.2007.12.005 Arends G, Schramm U. The structure of the human semilunar plica at different stages of its development a morphological and morphometric study [Internet]. Vol. 186, Annals of Anatomy - Anatomischer Anzeiger. Elsevier BV; 2004. p. 195–207. Available from: http://dx.doi.org/10.1016/S0940-9602(04)80002-5 Arends G, Schramm U. The structure of the human semilunar plica at different stages of its development a morphological and morphometric study [Internet]. Vol. 186, Annals of Anatomy - Anatomischer Anzeiger. Elsevier BV; 2004. p. 195–207. Available from: http://dx.doi.org/10.1016/S0940-9602(04)80002-5 Vokuda H, Heralgi M, Thallangady A, Venkatachalam K. Persistent unilateral nictitating membrane in a 9-year-old girl: A rare case report [Internet]. Vol. 65, Indian Journal of Ophthalmology. Medknow; 2017. p. 253. Available from: http://dx.doi.org/10.4103/ijo.IJO_436_15 García-Castro JM, Carlota Reyes de Torres L. Nictitating Membrane in Trisomy 18 Syndrome [Internet]. Vol. 80, American Journal of Ophthalmology. Elsevier BV; 1975. p. 550–1. Available from: http://dx.doi.org/10.1016/0002-9394(75)90228-7 Images Figure 1: Galloway, R. (2022, January 25). Lizard originally had a different look in 'Spider-Man: No way home'. We Got This Covered. Retrieved August 9, 2022, from https://wegotthiscovered.com/movies/lizard-originally-had-a-different-look-in-spider-man-no-way-home/ Figure 2: Hudson T. (2010, July) Retrieved Sep 13, 2022, from https://en.wikipedia.org/wiki/Nictitating_membrane#/media/File:Bir d_blink-edit.jpg Figure 3: Sharma R. Calabar angwantibo - Alchetron, The Free Social Encyclopedia [Internet]. Alchetron.com. 2018 [cited 7 May 2022]. Available from: https://alchetron.com/Calabar-angwantibo Figure 4: Amir, D. (2019, January 16). Twitter. Retrieved August 9, 2022, from https://twitter.com/dorsaamir/status/1085557444196 081664 Previous article Next article alien back to

< Back to Issue 4 PT by Saachin Simpson 1 July 2023 Edited by Caitlin Kane, Rachel Ko and Patrick Grave Illustrated by Jolin See 'Pt' (medical abbreviation for ‘patient’) recounts a patient visit on an early-morning ward round at Footscray Hospital in my first placement as a second-year medical student. The line “I came to hospital with my innocence” was actually said by the patient and stuck with me, eventually inspiring this poem, which I wrote in a Narrative Medicine class run by Dr Fiona Reilly and Dr Mariam Tokhi. The poem depicts a dramatic rise and fall in tension during the patient visit. It is bookended by soulless technical medical abbreviations that exemplify patient notes on electronic medical records. Pt Pt alert and oriented, sitting upright in chair. Breathing comfortably, responsive to questions. Bilat basal creps, bilat pitting oedema to knee. Pt gazes out window at the opposite concrete wall Pt’s cataracts suddenly shimmer, a sorcerer’s crystal ball. Pt need not speak for his stony grimace conveys Pt’s sheer and utter avowal of his final dying days. Pt’s power becomes apparent in his mighty ocular grip Pt’s lungs echo black tattered sails of a ramshackle timber ship. “I came to hospital with my innocence” Professional, qualified eyes dart from computer To patient And back. “and now I muse on dark and violent tricks” Med student looks at intern looks at reg looks at consultant. Feet shuffle, lips purse Pretending not to hear. “Your poisons gift no remedy, your words fat and hollow” Like a serpentine hiss, his derision rings through sterile air 5-step Therapeutic Guidelines for Reassurance (vol 23.4, updated 2023) does little for his despair. Pt need not speak for his stony grimace conveys Pt’s sheer and utter avowal of his final dying days. Pt need not speak for his stony grimace conveys Pt’s sheer and utter avowal of his final dying days. Pt to await GEM. Frusemide 40mmHg. Cease abx. Refer physio. Refer OT. Call family. For d/c Monday. Previous article Next article back to MIRAGE

By Andrew Lim From Fusion to Submarines: A Nuclear Year By Andrew Lim 23 March 2022 Edited by Tanya Kovacevic Illustrated by Quynh Anh Nguyen A press conference in April, pledging millions of dollars to nuclear medicine. A university address in November, rethinking Australia’s nuclear attitudes. A fusion reaction in December, promising a clean energy revolution. No matter where you were or who you were listening to, the world of nuclear science was inescapable in 2022. It has been a year of great progress and, at times, even greater controversy – pairing milestone triumphs and landmark facilities with old fears and vast challenges. So, what has defined the year in nuclear science – and what comes next? Powering the Future Image 1: LLNL’s National Ignition Facility, where the successful fusion ignition experiment was conducted in December. Perhaps the year’s most eye-catching discovery came near its end. On 13th December, scientists at the Lawrence Livermore National Laboratory (LLNL) in California announced that for the first time, they had produced more energy out of a nuclear fusion reaction than they had put in. It seemed to herald the beginnings of a new era – nuclear power without toxic nuclear waste. However, to report this as the USA’s civilian nuclear energy story of the year perhaps fails to capture the whole picture. It’s an important discovery, sure, but it stands on another development, far less well known: the congressional funding battles of the preceding months. Crafted from intense negotiations led by Majority Leader Chuck Schumer (D-NY) and Senators Todd Young (R-IN), Mark Warner (D-VA) and John Cornyn (R-TX), the bipartisan CHIPS and Science Act (1) authorized and appropriated funds for nuclear research en masse. It provided everything from a five-year $50 million p.a. plan for “Foundational Nuclear Science” (2), to a $1.09 billion Electron Ion Collider (3) and a “National Nuclear University Research Infrastructure Reinvestment” scheme that included LLNL (4). Even private sector fission work received a boost in the form of the Inflation Reduction Act of 2022 (5), built on a compromise between Schumer and Senator Joe Manchin (D-WV), allocating billions of dollars in tax credits and loan guarantees for the sector. These funding boosts (and their predecessors), the work of years of lobbying and negotiations across multiple political factions, helped create the environment necessary for this research to thrive – and the breakthrough is as much a reminder of their importance as a triumph of nuclear physics. Health and Safety Image 2: Prime Minister the Hon Scott Morrison MP, flanked by Health Minister the Hon Greg Hunt MP (L) and backbencher Gladys Liu MP (R), announces a $23 million APME grant in April. The year’s nuclear focus extended into the medical sector, too. President Biden’s 2022 State of the Union address announced an appeal beyond partisan lines, one pillar of which was the use of the Advanced Research Projects Agency for Health (ARPA-H) to “drive breakthroughs in cancer” (6). His call was answered in budget appropriations bills, funding accelerators and reactors to research new radioisotopes, while also investigating safer handling methods for natural and artificial nuclear sources (7). Such emphases echoed as far away as our antipodean shores. While Australia may already produce 80% of the radioisotopes used in its own nuclear medical procedures (8), both major parties took 2022 to advance nuclear medicine production. In April, the Coalition government launched new grants for the Australian Precision Medicine Enterprise (APME) in Melbourne, with the Hon Greg Hunt MP, then Minister for Health, declaring nuclear medicine “the next stage of precision medicine.” (9) Mere months later, in the October Budget, his Labor successor the Hon Mark Butler MP pledged funds for medical supplies of Gallium-67 (10). Across party lines, nuclear innovation became key to funding in the health sector. Securing Tomorrow Image 3: Australian Deputy Prime Minister and Minister of Defence Richard Marles (L) meets with US Secretary of Defence Lloyd J Austin III (R) at the Pentagon to discuss AUKUS submarine arrangements in December. All that said, no article about nuclear science, especially these days, would be complete without a discussion of AUKUS. In late October, an interview with Australian Vice Admiral Jonathan Mead was published in The Australian, in which he underscored the importance of building a nuclear workforce – that is, building the educational pathways required to produce all the crews, builders, architects, regulators and scientists a nuclear submarine capability would entail (11). With Australia’s first nuclear submarine captains likely in high school, the infrastructure needed to train them simply doesn’t exist – and time is running out. This urgency was emphasised by academics at ANU, home of the only postgraduate qualifications dedicated to nuclear science in the country. In November, Vice-Chancellor Brian Schmidt AC spoke of an approaching “transformation in Australia’s cultural relationship” with nuclear science (12). In December, Dr AJ Mitchell, an ANU academic leading the development of a national program for nuclear science and education, reiterated Schmidt’s arguments. In comments provided to The Sydney Morning Herald and The Age, he advocated for a “sovereign capability…start[ing] yesterday,” to ensure an Australian nuclear workforce capable of meeting requirements not only for defence but also for health, regulation, space exploration and much more (13). However, this attitude was not without controversy. In today’s world, where the word ‘nuclear’ carries connotations of Chernobyl, Fukushima, and the Cold War, increased nuclear funding (even if only to regulatory or medical bodies) often sparks fear in the public imagination. In response to Mitchell’s comments, A/Prof Peter Christoff, a University of Melbourne climate policy researcher, expressed worries about increased “anxiety in our region”. More than anything else, this perhaps underscores the biggest issue facing the nuclear sector: the long-held apprehensions from media, governments and beyond that can often lump anything vaguely nuclear – from medication to missiles – under the same roof. What's Next? Image 4: US President Joe Biden delivering his 2023 State of the Union Address, advocating for increased cancer research funding, flanked by Vice-President Kamala Harris (L) and Speaker Kevin McCarthy (R). Over the first months of 2023, the tense balancing acts and decisions of the past year have only continued to grow. In the USA, President Biden’s 2023 State of the Union speech, delivered in early February, saw him reinvigorate his call to “end cancer as we know it” (14) – the same call that led to all that radioisotope funding last year. However, Biden faces a Republican House of Representatives seemingly hell-bent on blocking his legislation. With the resultant impasse threatening a wholescale government shutdown, the funding necessary for scientific leaps of the kind seen in 2022 remains in doubt. On the Australian front, our lack of a ready nuclear workforce is causing jitters amongst our allies – with leaked letters from US Senators Jack Reed (D-RI) and James Inhofe (R-OK) expressing concern to the Biden administration about Australia relying on American production lines for stopgap submarines. Australian Defence Minister Richard Marles spent the December-January period allaying these concerns with the support of US Representatives Joe Courtney (D-CT-02) and Mike Gallagher (R-WI-08) while in the US and UK, but the issue is certain to remain a hot topic for this year. Even closer to home, Rio Tinto’s loss of a Caesium-137 capsule in Western Australia captured the imaginations of people across the nation and the world. At once it seemed to represent the long-standing fear of nuclear research and its importance in fuelling the same regulatory efforts that helped track down the capsule. Perhaps more than a story of scientific discoveries, of neutrons, protons and physics, the story of nuclear science in 2022 and beyond is the story of people. Of those legislators and politicians, balancing visions of the future with messy political compromises. Of those scientists and researchers, balancing plans and facilities with the capacity of their institutions. Of us, the ordinary public, balancing long-held phobias with exciting aspirations. Will we meet the challenges that lie before us? Are we ready to have a nuanced discussion about how we want to use our nuclear knowledge? Can we balance the possibilities of the future with the fears of the past? Well... that’s entirely up to us. Andrew Lim is an Editor and Feature Writer with OmniSci Magazine and spent the summer as a Summer Research Scholar at the Australian National University’s Heavy Ion Accelerator Facility, working on studying nuclear structure through particle transfer reactions. Image Credits (in order): Lawrence Livermore National Laboratory; Monash University; US Department of Defence; The White House Author's Note Between the submission of this article in late February and its publication in mid-March, a notable development took place, one that necessitated this additional note. On March 14, at an announcement held in San Diego, President Biden, Prime Minister Albanese and Prime Minister Sunak revealed plans for Australia to purchase three to five American Virginia-class submarines in the early 2030s. The Royal Navy and the Royal Australian Navy would then work out of their shipyards to develop and produce new SSN-AUKUS submarines (based off plans for successors to the British Astute-class models), coming into service in the late 2030s. If anything, this timeline accentuates the dramatic expansions required from Australia’s nuclear workforce, as presented in the original article. Meanwhile, the narrative that surrounded the announcement – one solely focussed on nuclear research’s military capabilities (and, at that, often conflating nuclear weaponry with nuclear power) – seems only to indicate the same throughlines of 2022 repeating themselves in the year to come…and nuanced and subtle discussion of nuclear research being left for another day. References CHIPS and Science Act, Pub L No 117-167, 136 Stat 1366 (2022). See ibid, div B tit I § 10102(d), 136 Stat 1415-6. See ibid, div B tit I § 10107, 136 Stat 1449-50, esp. sub-s (b)(4). See ibid, div B subtitle L § 10741-5, 136 Stat 1718-21. Inflation Reduction Act of 2022, Pub L No 117-169, 136 Stat 1818. The White House Office of the Press Secretary, Remarks by President Biden in State of the Union Address. March 2, 2022. https://www.whitehouse.gov/briefing-room/speeches-remarks/2022/03/02/remarks-by-president-biden-in-state-of-the-union-address/ See House Committee on Appropriations, Report to Accompany H.R. 8295, H.R. Rep No 117-403 (2022), esp. at 65, 104, 235, 238. Taylor A, Birmingham S and Hunt G, Safeguarding the future of critical medicine supply [Media Release]. September 30, 2021. https://www.minister.industry.gov.au/ministers/taylor/media-releases/safeguarding-future-critical-medicine-supply. “Precision medicine is the ‘future of medicine’: Greg Hunt”. The Australian. April 4, 2022. https://www.theaustralian.com.au/nation/politics/precision-medicine-is-the-future-of-medicine-greg-hunt/video/9ec9b0942bfb18757e3fbf4f3e95e0f4 Garvey, P. “Butler steps in to ease nuclear medicine crisis”. The Australian. October 27, 2022. Nicholson, B. “Defence Special Report: Cultivating a Nuclear Mindset”. The Australian. October 27, 2022. ANU Communications & Engagement, Building Australia’s AUKUS-ready nuclear workforce: Address by Professor Brian Schmidt AC. November 9, 2022. Mannix, L. “‘Cherish’ the power: Physicists issue call to arms over nuclear skills gap”. The Sydney Morning Herald. December 28, 2022. https://www.smh.com.au/national/cherish-the-power-physicists-issue-call-to-arms-over-nuclear-skills-gap-20221228-p5c92s.html The White House Office of the Press Secretary, Remarks by President Biden in State of the Union Address. February 7, 2023. https://www.whitehouse.gov/briefing-room/speeches-remarks/2023/02/07/remarks-by-president-biden-in-state-of-the-union-address-2/ Previous article Next article

By Yvette Marris Behind the Mask By Yvette Marris 23 March 2022 Edited by Tanya Kovacevic Illustrated by Quynh Anh Nguyen It would be hard to write about A Year in Science without the obligatory COVID article. We hear constantly about the stresses of being a frontline healthcare worker, the signs and symptoms of long COVID, and the endless vaccine scepticism. I’d like to tell a slightly different story. During the COVID pandemic, other infections didn’t just take a holiday and cancers didn’t just stop growing. More ordinary illness and injury continued behind the headlines. As a consequence of the pandemic, healthcare workers are additionally dealing with an abundance of patients, delays with diagnosis and some very complex medical cases. Megan Gifford worked in a hospital that didn’t primarily treat COVID-19 patients, but still had to adapt to the constant changing of rules, regulations and policies put in place to protect staff and patients alike from the virus. Now at the Peter MacCallum Cancer Centre in Melbourne, Gifford spoke to me about her experiences working at Townsville University Hospital in the only bone marrow transplant ward servicing a large population across regional Queensland. Gifford experienced the stress and burden of trying, not only to assuage their own anxieties but to also provide current, up-to-date information to patients and deliver high quality care. There were the frustrations of unavoidable logistical problems like border closures, stay-at-home orders, preventing access to crucial materials and patient transport. There was heartbreak of watching transplant patients deteriorate mentally, as their will to persist with treatments began to fade. Pathologists and haematologists also found themselves facing an unprecedented logistical nightmare, including re-allocation of diagnostic equipment and protective equipment for mass COVID testing. Access to essential biomedical material like blood and plasma became increasingly difficult and many suffered as a result. While pandemic consequences like long COVID and the increased prevalence of affective disorders, like depression and anxiety, are well documented in media and academia, post-traumatic stress disorder (PTSD) hasn’t gotten the same amount of attention. Statistics and anecdotes alike are staggering, both for patients and healthcare workers. With stressors like an unprecedented number of critically ill patients, capricious disease progressions, high mortality, and ever-changing treatment guidelines the world was sympathetic to healthcare workers’ struggles (3). Yet with the lockdowns and restrictions over, it would be naïve to think everything would just return to normal. It was found that 29% of healthcare workers had clinical or sub-clinical symptoms of PTSD (1), and that this figure was significantly higher for healthcare workers directly treating COVID patients (2). Gifford recalled anecdotes of “patients suffering anxiety attacks when they smell the hospital alcohol rub and hear the familiar beeping of the various equipment”. Even beyond the mental health scope, logistical issues like delayed learning for medical students or the backlog of elective procedures is still placing an enormous burden on healthcare workers, despite the immediate threat seemingly behind us. But to say that everything remains in shambles would frankly be insulting to healthcare workers, who are working tirelessly to deliver good quality healthcare. The speed at which pathologists and scientists have adapted to limited resources and supply shortages, and the way in which doctors and frontline workers have shifted their style of care and developed new problem-solving skills, are exceptional and should not go unnoticed or unappreciated. Importantly, the COVID-19 pandemic and its ripple effects have brought centre stage the consequences of under-resourced healthcare centres in a way that affected all people, irrespective of geography, class or reputation. The reality is that the conditions in which many metropolitan hospitals found themselves in, with never enough staff or supplies, is a condition that some hospitals experienced long before COVID-19 ever appeared, particularly in rural settings. To say that every dark cloud has a silver lining would be horribly cliché, but in this case, there may be truth to it. This edition of A Year in Science is a chance for us to reflect on all that COVID-19 has called attention to and decide to do something about it. References Carmassi C, Foghi C, Dell’Oste V, Cordone A, Bertelloni CA, Bui E, et al. PTSD symptoms in healthcare workers facing the three coronavirus outbreaks: What can we expect after the COVID-19 pandemic. Psychiatry Research. 2020 Oct;113312. Janiri D, Carfì A, Kotzalidis GD, Bernabei R, Landi F, Sani G. Posttraumatic Stress Disorder in Patients After Severe COVID-19 Infection. JAMA Psychiatry. 2021 Feb; Johnson SU, Ebrahimi OV, Hoffart A. PTSD symptoms among health workers and public service providers during the COVID-19 outbreak. Vickers K, editor. PLOS ONE. 2020 Oct 21;15(10):e0241032. Previous article Next article

By Lily McCann Svante Pääbo: Talking to the Past By Lily McCann 23 March 2022 Edited by Caitlin Kane Illustrated by Quynh Anh Nguyen For a collection of numbers on a screen, the World Population Clock stirs a lot of emotions (1). Watch it tick on, recording a life, another life, a death, then more lives. The number — well past 8 billion now — reflects the extent of Homo sapiens’ conquest over the world. Evidence of our culture, with its complex language, society and infrastructure, is everywhere. But we seem to be the only earthly species to live in such a way, the only species to track our own numbers on a digital clock. We swarm the planet, all its continents and yet we are, essentially, alone. To challenge this isolation, scientists reach out in all directions, hoping for some kind of reflection that might shed light on who we are. Astronomers look to space; they probe the depths of the universe in search of life like our own. Others, like Svante Pääbo, look to the past. 300,000 years ago, when Homo sapiens first evolved, there was no paper, no writing, no human-like language with which to record stories, cultures, or day to day recounts. Scant traces of our ancestors are all that are left to tease us: fossilised footprints, makeshift tools, bones, grave sites. These markers are indecipherable whispers, slipping through in a hazy, broken form from a past era to our own. With a time machine or resurrection tool perhaps we could converse with the dead, but while these remain foreign to our current reality, how can we talk to the past? For Pääbo, the language of genetics is the key. Using the information carried in Palaeolithic bones, Pääbo has discovered links between present-day humans and prehistoric hominids that tell the story of our evolution and current condition. These incredible findings have earnt Pääbo the Nobel Prize for Physiology or Medicine in 2022 (2). Some of his most important achievements establishing the field of Paleogenomics include the full sequencing of the Neanderthal genome and the discovery of a whole new hominin species: the Denisovan (3, 4). But what fascinates me is his discovery of genetic interrelations between these prehistoric species and Homo sapiens themselves. Pääbo compared Neanderthal and Denisovan genetics to those of modern humans across the world. He discovered similarities and patterns that suggest a flow of genes took place between our ancestors and these hominid species: in other words, our predecessors mingled sexually with Neanderthals and Denisovans at some point in history, passing their genetics onto us as encoded evidence of this fact (5). Human genomes from Europe and Asia were most closely related to Neanderthal genomes, and Pääbo has shown 1-2% of modern non-African Homo sapiens genes are Neanderthal in origin (3). Similar patterns were observed for Denisovans, with the closest relation with modern humans from Pacific islands (6). This data exposes an intimacy between prehistoric hominids that challenges our idea of humans as a species confined to solitude. This conversation between genomes is not without implications for modern human physiology. When Homo sapiens moved into Eurasia, Denisovan and Neanderthal locals had already adapted to places in which Homo sapiens were mere tourists (7). Transfer of certain genes from local populations into the Homo sapiens line may have assisted in their survival. One example is a gene found in Denisovans that is important for survival at high altitudes and has been inherited by modern day Tibetans (8). Researching the discrepancies between modern and prehistoric genetics can thereby allow us to show the function and significance of these shared genes. It is hard to visualise the world in which Neanderthals and Homo sapiens first met. Did the scene play out as a peaceful interaction between two groups of equals? Perhaps it was more akin to the pattern of colonisation with which we are familiar in modern history. As the last species of our evolutionary branch, the Homo genus, we cannot now recreate such a meeting. However these prehistoric meetings played out, we now have evidence that Homo sapiens and local species of hominids in Eurasia communicated on the most intimate of levels. An optimist might argue that these groups of pre-humans shared a harmonious understanding that could be reproduced if humans find an analogous life form elsewhere in the future. Communication is a powerful tool after all, traversing species and millennia. Perhaps genetic insights into the past can remind us that we are not really as isolated as we might think. References Current world population [Internet]. Worldometer. 2023 [cited 2023Mar7]. Available from: https://www.worldometers.info/world-population/ Hedestam GK, Wedell A. The Nobel Prize in Physiology or Medicine 2022 [Internet]. NobelPrize.org. The Nobel Foundation; 2022 [cited 2023Mar7]. Available from: https://www.nobelprize.org/prizes/medicine/2022/advanced-information/ Green RE, Krause J, Briggs AW, Maricic T, Stenzel U, Kircher M, et al. A draft sequence of the Neandertal genome. Science. 2010May7;328(5979):710–22. Krause J, Fu Q, Good JM, Viola B, Shunkov MV, Derevianko AP, et al. The complete mitochondrial DNA genome of an unknown hominin from southern Siberia. Nature. 2010Mar24;464(7290):894–7. Villanea FA, Schraiber JG. Multiple episodes of interbreeding between Neanderthal and modern humans. Nature Ecology & Evolution. 2018May26;3(1):39–44. Reich D, Patterson N, Kircher M, Delfin F, Nandineni MR, Pugach I, et al. Denisova admixture and the first modern human dispersals into Southeast Asia and Oceania. The American Journal of Human Genetics. 2011Oct11;89(4):516–28. Rogers AR, Bohlender RJ, Huff CD. Early history of neanderthals and Denisovans. Proceedings of the National Academy of Sciences. 2017Jul7;114(37):9859–63. Huerta-Sánchez E, Jin X, Asan, Bianba Z, Peter BM, Vinckenbosch N, et al. Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA. Nature. 2014;512(7513):194–7. Previous article Next article

< Back to Issue 7 Staying at the Top of Our Game: the Evolutionary Arms Race by Aizere Malibek 22 October 2024 edited by Rita Fortune illustrated by Aizere Malibek Organisms have been competing for biological domination since the beginning of life. Evolutionary adaptations arise from genetic mutations, which propel biodiversification and allow organisms with favourable traits to survive and reproduce. This is the foundation of Charles Darwin’s Theory of Evolution, explaining the rise of antimicrobial resistance and contagious viruses, while also offering solutions to these threats in public health and medicine. Mutations in the DNA of pathogens allow them to adapt to our immunological defences and invade our bodies. Conversely, the variation in our immune cells allows us to detect and defend against pathogens as a counter-adaptation. Medicine has advanced dramatically in the recent decades, with novel vaccines, antivirals and antibiotics being developed quicker than ever before. Unfortunately, persistent pathogens have found a way to survive attacks from our immune systems and drugs, making it difficult to devise an effective cure for these infections. Take HIV, for instance: the virus activates programmed cell-death in our CD4+ T immune cells and alters their metabolism as a survival mechanism (Gougeon, 2003; Palmer et al., 2016). In turn, this directly reduces the immune system’s ability to defend against the virus. This is further complicated by the high mutation rate of HIV, leading to rapid resistance to various treatment options (Gupta et al., 2018). Fortunately, scientific discoveries are helping us develop solutions for infectious diseases. It was found that HIV is susceptible to immune responses in its initial immature stages, which has become a target of the current pursuits in vaccine development for the virus (Picker et al., 2012). Vaccines are beneficial in these cases because they expose memory cells in order to inactive microbial antigens, which are a key cell involved in our active immune responses. This allows our bodies to tackle the pathogens more efficiently, reducing the symptoms and long-term effects of infection. Another emerging treatment option is through CRISPR-Cas9 technology. Originally discovered as a bacterial defence system against viruses, CRISPR allows scientists to precisely edit genes. This technology is being explored not only for its potential to correct genetic disorders, but also as a weapon against pathogens. Researchers are looking into using CRISPR to target viral DNA in infected human cells, cutting it out before the virus can replicate (Mengstie & Wondimu, 2021). If successful, CRISPR could be a game-changer in the fight against diseases like HIV, influenza, and even the next pandemic. However, HIV is just one example of this ongoing evolutionary arms race between pathogens and humans. The phenomenon isn’t restricted to just viruses; bacteria and fungi have also become significant opponents. The rise of antibiotic resistance in bacteria is an alarming and rising public health issue today. Antibiotics are increasingly losing their efficacy due to misuse and overprescription. Pathogens like Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ) have developed multiple resistance mechanisms, including the production of enzymes that break down the antibiotic molecules before they can exert their effect (Reygaert, 2018). Methicillin-resistant Staphylococcus aureus (MRSA) is a prime example of antibiotic resistance. Initially, methicillin was developed to treat penicillin-resistant strains of bacteria. However, as methicillin became widely used, new strains of S. aureus emerged that could resist the potent drug. MRSA infections are now incredibly difficult to treat and pose a serious public health threat, particularly in hospitals and healthcare settings where immunocompromised patients are most vulnerable (Collins et al., 2010). Vaccines are not as effective against bacteria and fungi due to the more complex structures of these organisms. So how do we stay ahead in this race? One promising area of research is the development of next-generation antibiotics and antivirals. Researchers are now investigating bacteriophages—viruses that specifically infect bacteria—as a potential solution to antibiotic-resistant infections. These phages, which evolve alongside bacteria, could be used to target and destroy harmful bacterial strains without the collateral damage caused by traditional antibiotics (Plumet et al., 2022). While scientific innovation is key to staying ahead in the evolutionary arms race, public health policies play an equally important role. Misuse of antibiotics, for instance, has significantly accelerated the rise of antibiotic-resistant bacteria outside healthcare settings (David & Daum, 2010). Governments and healthcare organisations are now pushing for stricter regulations on antibiotic prescriptions and promoting the responsible use of these drugs. Global collaboration is also essential. Pathogens don’t respect national borders, and the spread of infectious diseases is a global issue. Initiatives like the World Health Organisation’s Global Antimicrobial Resistance Surveillance System (GLASS) are crucial in monitoring and controlling the spread of resistant pathogens worldwide. By sharing data and resources, countries can better coordinate their responses to emerging threats, mitigating the risks posed to global health. The dynamic shifts in power between humans and pathogens continues to unfold in this evolutionary arms race. While scientific innovation is allowing the development of new tools, from vaccines to gene-editing technologies, we must also adopt policies that promote responsible drug use and global cooperation. In this race, staying at the top of our game requires constant vigilance, innovation, and adaptation—because pathogens certainly aren’t slowing down. The stakes are high, but with continued research and collaboration, we have the potential to maintain the upper hand in this ever-evolving battle for survival. References Collins, J., Rudkin, J., Recker, M., Pozzi, C., O'Gara, J. P., & Massey, R. C. (2010). Offsetting virulence and antibiotic resistance costs by MRSA. Isme Journal, 4(4), 577-584. https://doi.org/10.1038/ismej.2009.151 David, M. Z., & Daum, R. S. (2010). Community-Associated Methicillin-Resistant Staphylococcus aureus : Epidemiology and Clinical Consequences of an Emerging Epidemic. Clinical Microbiology Reviews, 23(3), 616-+. https://doi.org/10.1128/cmr.00081-09 Gougeon, ML. Apoptosis as an HIV strategy to escape immune attack. Nat Rev Immunol 3 , 392–404 (2003). https://doi.org/10.1038/nri1087 Gupta, R. K., Gregson, J., Parkin, N., Haile-Selassie, H., Tanuri, A., Forero, L. A., Kaleebu, P., Watera, C., Aghokeng, A., Mutenda, N., Dzangare, J., Hone, S., Hang, Z. Z., Garcia, J., Garcia, Z., Marchorro, P., Beteta, E., Giron, A., Hamers, R., . . . Bertagnolio, S. (2018). HIV-1 drug resistance before initiation or re-initiation of first-line antiretroviral therapy in low-income and middle-income countries: a systematic review and meta-regression analysis. Lancet Infectious Diseases, 18(3), 346-355. https://doi.org/10.1016/s1473-3099(17)30702-8 Mengstie, M. A., & Wondimu, B. Z. (2021). Mechanism and Applications of CRISPR/Cas-9-Mediated Genome Editing. Biologics-Targets & Therapy, 15, 353-361. https://doi.org/10.2147/btt.S326422 Palmer, C. S., Cherry, C. L., Sada-Ovalle, I., Singh, A., & Crowe, S. M. (2016). Glucose Metabolism in T Cells and Monocytes: New Perspectives in HIV Pathogenesis. EBioMedicine, 6, 31–41. https://doi.org/10.1016/j.ebiom.2016.02.012 Picker, L. J., Hansen, S. G., & Lifson, J. D. (2012). New Paradigms for HIV/AIDS Vaccine Development. In C. T. Caskey, C. P. Austin, & J. A. Hoxie (Eds.), Annual Review of Medicine, Vol 63 (Vol. 63, pp. 95-111). https://doi.org/10.1146/annurev-med-042010-085643 Plumet, L., Ahmad-Mansour, N., Dunyach-Remy, C., Kissa, K., Sotto, A., Lavigne, J. P., Costechareyre, D., & Molle, V. (2022). Bacteriophage Therapy for Staphylococcus Aureus Infections: A Review of Animal Models, Treatments, and Clinical Trials. Frontiers in cellular and infection microbiology, 12, 907314. https://doi.org/10.3389/fcimb.2022.907314 Reygaert, W. C. (2018). An overview of the antimicrobial resistance mechanisms of bacteria. Aims Microbiology, 4(3), 482-501. https://doi.org/10.3934/microbiol.2018.3.482 Previous article Next article apex back to

< Back to Issue 7 Fossil Markets: Under the Gavel, Under Scrutiny by Jesse Allen 22 October 2024 edited by Zeinab Jishi illustrated by Jessica Walton At the crossroads between science and commerce, the trade in fossils has "developed into an organised enterprise" over the course of the twentieth century. With greater investment and heated competition between museums and private collectors, fossils increasingly took their place alongside “art, furniture, and fine wine” (Kjærgaard, 2012, pp.340-344). Fast forward to the twenty-first century, and this trend shows no signs of abating. On the contrary: as of 10 July 2024, a near-complete stegosaurus skeleton - nicknamed ‘Apex’ - was discovered by a commercial palaeontologist in Colorado, and was later purchased by “hedge-fund billionaire” Ken Griffin for US$44.6 million (Paul, 2024). This makes it the single most expensive dinosaur skeleton ever sold, eclipsing the previous record set in 2020 for a T-Rex named ‘Stan’, who was snapped up for US$31.8 million (Paul, 2024). These sales came with their fair share of criticism and controversy, reigniting the long-standing debate about how fossils should be handled, and where these ancient remains rightfully belong. Fossils (from the Latin fossilus , meaning ‘unearthed’) are the “preserved remains of plants and animals” which have been buried in sediments or preserved underneath ancient bodies of water, and offer unique insights into the history and adaptive evolution of life on Earth (British Geological Survey, n.d.). Their value is by no means limited to biology, however: they are useful for geologists in correlating the age of different rock layers (British Geological Survey, n.d.), and reveal the nature and consequences of changes in Earth’s climate (National Park Service, n.d.). Though new discoveries are being made all the time, fossils are inherently a finite resource, which cannot be replaced. This is part of what makes the fossil trade so lucrative, but the forces of limited supply and high demand have also led to the emergence of a dark underbelly. Cases of fossil forgery go back “as far as the dawn of palaeontology itself” in the late 18th and 19th centuries (Benton, 2024). The latest “boom in interest" is massively inflating prices and “fuelling the illicit trade” in fossils (Timmins, 2019). Whereas the US has a ‘finders-keepers’ policy, according to which private traders have carte blanche to dig up and sell any fossils they find, countries such as Brazil, China, and Mongolia do not allow the export of specimens overseas (Timmins, 2019). Sadly, this does little to prevent illegal smuggling; the laws are sometimes vague, and enforcement can be difficult when no single government agency is responsible for monitoring palaeontological activities (Winters, 2024). According to David Hone, a reader in zoology at Queen Mary University of London, “not every fossil is scientifically valuable”; but they are all “objects…worthy of protection,” and too many “scientifically important fossils appear briefly on the auction house website” before “vanish[ing] into a collector’s house, never to be seen again” (Hone, 2024). Museums, universities, and other scientific organisations are finding it more and more difficult to “financially compete with wealthy, private purchasers” as they are simply being priced out of the market (Paul, 2024). As sales become less open to expert scrutiny, the risk of forgery and price distortions become greater. It also has negative implications for future research. Private collectors might give access to one scientist, but not allow others to corroborate their findings. If the fossils aren’t open to all, many institutions simply won’t examine the items in private collections as a matter of principle. (Timmins, 2019). The general public also loses out in a world where dinosaur fossils are reduced to expensive conversation pieces. As Hone writes, “we might never dig up another Stegosaurus, or never find one nearly as complete as [Apex].” Having waited 150 million years to be unearthed, this latest fossil is one of many that may not see the light of day for a very long time. Bibliography Benton, M. (2024, September 5). Modern palaeontology keeps unmasking fossil forgeries – and a new study has uncovered the latest fake . The Conversation. https://theconversation.com/modern-palaeontology-keeps-unmasking-fossil-forgeries-and-a-new-study-has-uncovered-the-latest-fake-223501 British Geological Survey. (n.d.). Why do we study fossils? British Geological Survey. https://www.bgs.ac.uk/discovering-geology/fossils-and-geological-time/fossils/ Hone, D. (2024, June 10). The super-rich are snapping up dinosaur fossils – that’s bad for science . The Guardian. https://www.theguardian.com/commentisfree/article/2024/jun/10/super-rich-dinosaur-fossils-stegosaurus-illegal-trade-science Kjærgaard, P. C. (2012). The Fossil Trade: Paying a Price for Human Origins. Isis , 103 (2), 340–355. https://doi.org/10.1086/666365 National Park Service. (n.d.). The significance of fossils . U.S. Department of the Interior. https://www.nps.gov/subjects/fossils/significance.htm Paul, A. (2024, July 18). Stegosaurus 'Apex' sold for nearly $45 million to a billionaire . Popular Science. https://www.popsci.com/science/stegosaurus-skeleton-sale/ Timmins, B. (2019, August 8). What’s wrong with buying a dinosaur? BBC News. https://www.bbc.com/news/business-48472588 Winters, G.F. (2024). International Fossil Laws. The Journal of Paleontological Sciences , 19 . https://www.aaps-journal.org/Fossil-Laws.html Previous article Next article apex back to

< Back to Issue 7 A Coral’s Story: From thriving reef to desolation by Nicola Zuzek-Mayer 22 October 2024 edited by Arwen Nguyen-Ngo illustrated by Amanda Agustinus The sun is shining. Shoals of fish are zooming past me, leaving their nests where I let them stay for protection from bigger fish. I look to my right and the usual fish have come to dine from me, filling their bellies with vital nutrients. I feel proud of our coexistence: I feed the big fish and provide shelter to small fish, whilst they clean algae off of me. I am the foundation of the reef. I am the architect of the reef. Without me, there would be nothing. I can’t help but think that the reef is looking vibrant today. A wide variety of different coloured corals surround me in the reef, with some of my closest friends a stone’s throw away. We’ve all known each other for our entire lives, and it’s such a close knit community of diverse corals. Life is sprawling in this underwater metropolis, and it reminds me of how much I love my home. But recently, I’ve heard some gossip amongst the city’s inhabitants that this paradise may change soon – and for the worse. Something about the land giants destroying our home. I refuse to believe such rumours – why would they want to destroy us? Our home is so beautiful, and we have done nothing to hurt them. Our beauty attracts many of them to come visit us, and most never hurt us. But sometimes I feel pain when they visit on a particularly sunny day, when I see white particles drop down to the reef and pierce my branches, polluting the city. My friends have told me that these giants wear something called ‘sunscreen’ to protect themselves from the sun, but their ‘protection’ is actually poisoning us. I hope that they realise that soon. Another thing that I’ve noticed recently is that the ocean is feeling slightly warmer than before, and my growth is slowing more. Yes, I’m concerned, but I don’t think that the issue will get worse. 30 years later… The sun is blisteringly hot. I feel sick and the water around me is scorching hot. The vibrant colours of the reef are disappearing, and there are fewer organisms around. We used to be so diverse, but so many species of fish have died out. It’s eerie to see the area so desolate. My body is deteriorating and I feel so much more fragile than before. I feel tired all the time, after using so much energy to repair my body in the acidic water. I sense myself becoming paler, losing all colour in my body. I struggle to breathe. My coral friends and family are long gone, perished from the acidity of the ocean. I am the last one remaining. In my last moments, I can only wish to go and relive the past. I wish that the land giants had done more to help not only my city, but other reef cities around the world. All the other cities are empty now, and all ecosystems are long gone. If only someone had helped our dying world. Previous article Next article apex back to

< Back to Issue 2 Making sense of the senses: The 2021 Nobel Prize in Physiology or Medicine What do spicy food, menthol lozenges and walking around blindfolded have in common? They all activate protein receptors discovered by Professors David Julius and Ardem Patapoutian, the winners of the 2021 Nobel Prize in Physiology or Medicine. by Dominika Pasztetnik 10 December 2021 Edited by Breana Galea & Juulke Castelijn Illustrated by Casey Boswell Stimuli are changes to our environment, such as heat, cold and touch, that we recognise through our senses. We are all constantly bombarded with thousands of these stimuli from our surroundings. Despite this disorder, we are somehow able to perceive and make sense of the world. The protein receptors discovered by Professors Julius and Patapoutian make this possible. Located at the surface of the nerve cell, these receptors convert an external stimulus to an electrical signal. This signal then travels along nerve cells to the brain, allowing us to sense the stimulus. Based in California, Julius and Patapoutian are scientists in the fields of neuroscience and molecular biology. The main interest of their work has been identifying and understanding the protein receptors involved in detecting stimuli. For Julius, his major focus has been to identify the receptors involved in the sensation of pain (1). For Patapoutian, it has been to identify the protein receptors involved in detecting mechanical stimuli, such as touch (2). For their past 25 years of research, Julius and Patapoutian were awarded the Nobel Prize in Physiology or Medicine in October 2021. The Nobel Prize was founded by Alfred Nobel, a Swedish scientist also famous for inventing dynamite. Prior to his death in 1896, Nobel allocated most of his money to the first Nobel Prizes. Since 1901, the Nobel Prize has been annually bestowed on those who, in Nobel’s words, have “conferred the greatest benefit to mankind” in different fields (3). Notable past laureates of the Nobel Prize in Physiology or Medicine include Sir Alexander Fleming, Sir Ernst Chain and the Australian Howard Florey. They were awarded in 1945 for their discovery of the antibiotic penicillin (4). Sir Hans Krebs received the Nobel Prize in 1953 for his discovery of the citric acid cycle (5). Also known as the Krebs cycle, it is a series of reactions used to produce energy in our cells. TRPV1: spice it up It’s a rather chilly morning. You eye the packet of Shin Ramyun that’s been sitting in your pantry for weeks. Without a second thought, you prepare the noodles, adding all the soup powder. After a few mouthfuls, your eyes start streaming and your face matches the scarlet red of the now-empty packaging. The culprit is capsaicin, a substance in the chilli flakes added to the soup powder. It binds to a protein receptor embedded at the surface of the nerve cells in your mouth. Julius discovered this receptor in 1997, and called it TRPV1, which stands for transient receptor potential vanilloid type 1 (6). TRPV1 is a channel with a gate at either end that is usually closed (Figure 1, blue) (7). Capsaicin opens these gates, allowing ions, such as calcium, to move through TRPV1 and into the nerve cell (Figure 1, red). The nerve cell then signals to the brain, causing you to feel the searing heat in your mouth. TRPV1 is also found in your skin and can be activated by temperatures above 40°C, such as when you accidentally touch the kettle full of boiling water for your noodles (8). Figure 1. TRPV1 at the surface of a nerve cell. In the absence of capsaicin or at cool temperatures, TRPV1 is closed (blue). In the presence of capsaicin or at higher temperatures, TRPV1 opens, allowing ions to flow into the nerve cell (red). TRPM8: too cool for school On your way to uni, you notice your throat’s a bit sore from going overboard with karaoke the night before, so you pop a lozenge into your mouth. The soothing, cool sensation is thanks to menthol. It is a compound that binds to TRPM8, which stands for transient receptor potential melastatin 8. It is another receptor found on the nerve cells in your tongue, as well as on your skin (9). TRPM8 was separately discovered in 2002 by both Julius and Patapoutian (10). Like TRPV1, TRPM8 is a protein channel that is usually closed. In response to menthol or cool temperatures from 26 down to 8°C, TRPM8 opens and allows ions to enter the nerve cell, which then signals the cold sensation to your brain (11). PIEZO: peer pressure During your lunch break at uni, you and your mates decide to play blindfolded tag. Because, as we all know, that's what uni students do in their free time. In the first round, you have the misfortune of being chosen as ‘it’. Blindfolded, you walk around with your hands in front of you, trying to find your mates. Despite not being able to see anything, you can still walk and wave your arms and roughly know where your arms and legs are in space. This is due to a sense called proprioception. You lunge forward and nearly grab someone, only to feel their jacket brush your fingers. Both proprioception and the detection of light touch, such as of the jacket brushing your fingers, are made possible by another class of protein receptors called PIEZO2. Discovered by Patapoutian in 2010, its name comes from piesi, the Greek word for pressure (12). Like TRPV1 and TRPM8, PIEZO2 is an ion channel at the nerve cell surface. However, the structure of PIEZO2 is nothing like that of TRPV1 and TRPM8. PIEZO2 has three protruding blades, which form a dent, called a nano-bowl, in the outer surface of the cell (13). When the outside of the cell is prodded, the blades straighten and the nano-bowl flattens. This allows the channel in the centre of the PIEZO2 to open, so ions can flow into the nerve cell (Figure 2). The nerve cell then sends an electrical impulse to the brain, letting you know you’re failing at blindfolded tag. Figure 2. PIEZO at the surface of a nerve cell. When force is applied to the surface of the nerve cell, the PIEZO channel opens, allowing ions to move into the cell. Apart from being essential for playing blindfolded tag, PIEZO2 is also important in various other aspects of the human body’s functioning we often take for granted. For example, PIEZO2 prevents you from breathing in too much air (14). It is also present on the cells lining your digestive tract. PIEZO2 detects pressure exerted onto these cells by food, causing the cells to release hormones that help with digestion (15). Furthermore, PIEZO2 helps monitor the fullness of your bladder, saving you from embarrassment (16). If there is a PIEZO2, what about PIEZO1? Although it has a similar structure to PIEZO2, PIEZO1’s role is quite different. PIEZO1 handles the background maintenance required to keep your body healthy. This includes bone formation (17) and preventing your red blood cells from bursting (18). People with a particular mutated form of PIEZO1 have a reduced risk of getting malaria (19). Patapoutian found that this mutation causes red blood cells to shrivel, preventing the malaria parasite from infecting them. Many people living in malaria-affected areas, such as Africa, have this mutation. Therefore, knowledge regarding these receptors is improving our understanding of related diseases. Drug development Researchers are currently using information about the receptors discovered by Julius and Patapoutian to develop new drugs to treat various conditions. Knowing the identities and structures of these receptors is helping researchers design compounds that bind to them, either blocking or activating them. In this way, Julius and Patapoutian’s work is helping provide a “benefit to mankind”. For example, during a migraine, the TRPV1 channel opens more frequently in the nerve cells of the meninges, the envelope surrounding the brain (20). These nerve cells contain more TRPV1 at their surfaces. This causes the nerve cells to send more electrical signals to the brain and so increases the sensation of pain. Using a drug to block the TRPV1 receptor could reduce the number of these electrical impulses and lessen the pain associated with migraines. It’s been a busy day activating all these receptors, which, as it turns out, are part of your daily life as a uni student. So next time you eat chilli flakes, have a menthol lozenge or play blindfolded tag, you will know which tiny sensors to hold responsible for your pleasant — or unpleasant — experiences. Further reading Press release: The Nobel Prize in Physiology or Medicine 2021 The Nobel Prize in Physiology or Medicine 2021 - Advanced Information References: University of California San Francisco. “Biography of David Julius.” UCSF. Accessed November 10, 2021. https://www.ucsf.edu/news/2021/09/421486/biography-david-julius. Nobel Prize Outreach AB 2021. “Press release: The Nobel Prize in Physiology or Medicine 2021.” The Nobel Prize. Accessed November 10, 2021. https://www.nobelprize.org/prizes/medicine/2021/press-release/. Nobel Prize Outreach AB 2021. "Alfred Nobel’s will." The Nobel Prize. Accessed November 10, 2021. https://www.nobelprize.org/alfred-nobel/alfred-nobels-will/. Nobel Prize Outreach AB 2021. “The Nobel Prize in Physiology or Medicine 1945.” The Nobel Prize. Accessed November 10, 2021. https://www.nobelprize.org/prizes/medicine/1945/summary/ Nobel Prize Outreach AB 2021. “The Nobel Prize in Physiology or Medicine 1953.” The Nobel Prize. Accessed November 10, 2021. https://www.nobelprize.org/prizes/medicine/1953/summary/ Ernfors, Patrik, Abdel El Manira, and Per Svenningsson. "Advanced information." The Nobel Prize. Accessed November 10, 2021. https://www.nobelprize.org/prizes/medicine/2021/advanced-information/. Liao, M., E. Cao, D. Julius, and Y. Cheng. "Structure of the Trpv1 Ion Channel Determined by Electron Cryo-Microscopy." Nature 504, no. 7478 (Dec 5 2013): 107-12. doi: 10.1038/nature12822. Ernfors et al., “Advanced information.” McKemy, D. D. "Trpm8: The Cold and Menthol Receptor." In Trp Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades, edited by W. B. Liedtke and S. Heller. Frontiers in Neuroscience. Boca Raton (FL), 2007. Ernfors et al., “Advanced information.” McKemy, Trp Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades. Coste, B., J. Mathur, M. Schmidt, T. J. Earley, S. Ranade, M. J. Petrus, A. E. Dubin, and A. Patapoutian. "Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels." Science 330, no. 6000 (Oct 1 2010): 55-60. doi: 10.1126/science.1193270. Jiang, Y., X. Yang, J. Jiang, and B. Xiao. "Structural Designs and Mechanogating Mechanisms of the Mechanosensitive Piezo Channels." Trends in Biochemical Sciences 46, no. 6 (Jun 2021): 472-88. doi: 10.1016/j.tibs.2021.01.008. Nonomura, K., S. H. Woo, R. B. Chang, A. Gillich, Z. Qiu, A. G. Francisco, S. S. Ranade, S. D. Liberles, and A. Patapoutian. "Piezo2 Senses Airway Stretch and Mediates Lung Inflation-Induced Apnoea." Nature 541, no. 7636 (Jan 12 2017): 176-81. doi: 10.1038/nature20793. Alcaino, C., K. R. Knutson, A. J. Treichel, G. Yildiz, P. R. Strege, D. R. Linden, J. H. Li, et al. "A Population of Gut Epithelial Enterochromaffin Cells Is Mechanosensitive and Requires Piezo2 to Convert Force into Serotonin Release." Proceedings of the National Academy of Sciences of the United States of America 115, no. 32 (Aug 7 2018): E7632-E41. doi: 10.1073/pnas.1804938115. Marshall, K. L., D. Saade, N. Ghitani, A. M. Coombs, M. Szczot, J. Keller, T. Ogata, et al. "Piezo2 in Sensory Neurons and Urothelial Cells Coordinates Urination." Nature 588, no. 7837 (Dec 2020): 290-95. doi: 10.1038/s41586-020-2830-7. Li, X., L. Han, I. Nookaew, E. Mannen, M. J. Silva, M. Almeida, and J. Xiong. "Stimulation of Piezo1 by Mechanical Signals Promotes Bone Anabolism." Elife 8 (Oct 7 2019). doi: 10.7554/eLife.49631. Cahalan, S. M., V. Lukacs, S. S. Ranade, S. Chien, M. Bandell, and A. Patapoutian. "Piezo1 Links Mechanical Forces to Red Blood Cell Volume." Elife 4 (May 22 2015). doi: 10.7554/eLife.07370. Ma, S., S. Cahalan, G. LaMonte, N. D. Grubaugh, W. Zeng, S. E. Murthy, E. Paytas, et al. "Common Piezo1 Allele in African Populations Causes Rbc Dehydration and Attenuates Plasmodium Infection." Cell 173, no. 2 (Apr 5 2018): 443-55 e12. doi: 10.1016/j.cell.2018.02.047. Dux, M., J. Rosta, and K. Messlinger. "Trp Channels in the Focus of Trigeminal Nociceptor Sensitization Contributing to Primary Headaches." International Journal of Molecular Sciences 21, no. 1 (Jan 4 2020). doi: 10.3390/ijms21010342. Previous article back to DISORDER Next article

By Caitlin Kane, Rachel Ko, Patrick Grave, Yvette Marris Message from the Editors in Chief By Caitlin Kane, Rachel Ko, Patrick Grave, Yvette Marris 23 March 2022 Edited by the Committee Illustrated by Quynh Anh Nguyen Another year in science has passed, with 2022 disappearing into 2023. With a mandated return to campus life at the University, there seems a tangible break from the past three years of lockdowns, isolation and online existence. Over the summer holidays, four of our wonderful OmniSci contributers—Andrew, Julia, Lily and Yvette—have written about science that has made a mark in 2022, with topics spanning DNA of the ancient past to the future of art crafted by artificial intelligence. Our writers were supported by editors, Tanya and myself, and the cover and article art for this issue has been created by Quynh Anh. Thanks also goes to our behind-the-scenes events duo, Andrew (again!) and Aisyah, who have been working hard on promotion to showcase the work of our team on this mini-issue, and our treasurer-secretary, Maya, who keeps us all in line. On behalf of the whole team, we're incredibly excited to share our summer issue, 2022: A Year in Science. If you would like to support our work, you can sign up as a member, join our mailing list or get in touch at omniscimag@gmail.com—all this and more on our About Us page. Most importantly, please read on! Previous article Next article

< Back to Issue 6 A Brief History of the Elements: Finding a Seat at the Periodic Table by Xenophon Papas 28 May 2024 Edited by Arwen Nguyen-Ngo Illustrated by Rachel Ko What are we made of and where did it all come from? Such questions have pervaded the minds of scientific thinkers since ancient times and have entered all fields of enquiry, from the physical to the philosophical. Our best scientific theory today asserts that we’re made of atoms, and these atoms come in different shapes and sizes. Fundamentally, they can be described by the number of subatomic particles (protons, neutrons, and electrons) they contain (Jefferson Lab, 2012). Neatly arranged in a grid, these different elements form the periodic table we know and love today; but it was not always this way. The story of how the periodic table of elements came to be harks back to Ancient Greece and winds its way through the enlightenment into the 20th century. It is an unfinished story of which we are at the frontier of today: in search of dark matter and the ultimate answer to what the universe is made of. We may never know for sure exactly what everything in existence consists of, but it’s a pursuit our earliest ancestors would be proud to see us follow. Thales was first in the ancient Greek-speaking world to postulate about the origins of all material things. He theorised that all matter in the universe was made up of just one type of substance – water – and any other forms of solids, liquids and gases were just derivatives thereof. This idea was not initially opposed, given Thales was one of the earliest of the Ancient Greeks to pursue such questions of a scientific nature. Afterall, he’s remembered today as the “Father of Science” in the Western world. As Thales was from Miletus, a city on the coast of the Ionian Sea in modern day Türkiye and part of Magna Graecia in the 6th cent BC, it is not hard to imagine that water was a crucial aspect in trade, agriculture, and daily life at the time. However, this seemed to oversimplify the matter to some of his contemporaries. Empedocles, who was considered more a magician than a philosopher, revised this mono-elemental theorisation in the 5th Century BC. He proposed four basic substances from which all others were made (Mee, 2020). We know them today famously as the four classical elements: Earth, Air, Water and Fire. This asserted a fundamental principle of “fourness”, encompassing the cardinal directions in the Western world during this time. Interestingly, concurrent to this other traditions such as those in China acknowledged five elements and compass points instead. A generation later to Empedocles’ work, Plato embraced his “fourish” formulation. Being heavily influenced by mathematics as the medium through which we make reason of the natural world, Plato related each of these elements to a mathematical object: a convex, regular polyhedron in three-dimensional Euclidean space, otherwise known as a Platonic solid. Earth was associated with the cube, air with the octahedron, water with the icosahedron, and fire with the tetrahedron. Lastly, the most complicated solid, the dodecahedron – itself made up of composite regular polygons – was associated with the makeup of the constellations and the Heavens themselves, their workings said to be unfathomable by human minds (Ball, 2004). His student, Aristotle, ran with this idea and devised a clever way to break up the elements based on their "qualities”, akin to a first periodic table. These binary roles were hot and cold, wet and dry, with an element containing just two of these qualities each. According to Aristotle, each of these elements could be converted to the other by inverting one of their qualities, seemingly bringing about an early form of alchemy. To these four elements, he also appended a fifth - aether or “pure air” - to fill the expanses of the heavens, which also became associated with the fifth Platonic solid. In the Western World, Aristotle’s word was taken as doctrine for a very long time owing greatly to the fall of Rome and the cultural instability thereafter. Where Europe plummeted into the Dark Ages with a reverence for the scholars of antiquity, scientific and literary endeavour flourished in the Middle East – the word alchemy itself having etymologically Arabic roots. It was not until the late 17th century that the likes of Galileo, Newton, and Descartes revived Western scientific pursuit, and sought to understand how the natural world arranged itself. In the 18th century, new discoveries were being made on the frontiers of science in major cities throughout Europe. In 1772, in Paris, Antoine Lavoisier began work on combustion of materials like phosphorus and sulphur. Lavoisier concluded that if something decomposes into simpler substances, then it is not an element. For example, while water can be turned into a gas when passed over hot iron and is therefore not an element, oxygen and hydrogen are indeed elemental. English chemist John Dalton took after Lavoisier and in 1808 began to arrange elements spatially into a chart, accounting for their various properties. In Strasbourg 1827, Wolfgang Döbereiner recognised that groups of threes arose from the list of elements which behaved similarly, known as “Döbereiner's triads" (Free Animated Education, 2023). John Newlands in 1866 put forward the “Law of Octaves”. Elements with similar properties ended up at regular intervals, dividing the elements into seven groups of eight – hence octaves. However, this method of dividing up the elements broke down in some special cases. Now turning to St. Petersburg, Russia, in February of 1869. Dmitri Mendeleev sits at his desk, with a mess of cards covering the surface of his working space. The professor of chemistry rearranges these elemental cards like a jigsaw puzzle, arranging and rearranging them to align them in accordance with their properties. Supposedly after coming to him in a dream, a pattern emerged. Mendeleev saw the ability for the simple tabulation of the elements based on their atomic number and hence their common properties. This newfound tool, based on Lavoisier’s work a century prior, allowed for the prediction of properties of elements which had not even been discovered yet. Elements which Mendeleev believed to exist, even though they presented as empty gaps in the grid structure of the periodic table. Within just twenty years, Mendeleev’s prediction of the existence of such elements like gallium, scandium, and germanium had been validated with experimental fact. All of this was predicted without knowledge of the true reason for similarities of elemental properties – the electron shell arrangement at a subatomic level. Mendeleev had totally changed the way chemists viewed their discipline and has been immortalised for perhaps the greatest breakthrough work in the history of chemistry (Rouvray, 2019). Today we recognise that all the elements in the universe have origins in the high-pressure hearts of stars. Like a hot furnace, they churn out heavier and heavier elements under their immense internal pressures. Once this life cycle comes to an end, the star erupts into a fiery supernova, releasing even more of the heavier elements we see further down the periodic table. In the last 75 years, scientists have added an additional 24 elements to the periodic table, some of which are so difficult to produce that their half-lives last only a few fractions of a millisecond before decaying away to nothing (Charley, 2012). This begs the question; how do we find new elements? Elements can be created via either fission, splitting apart a heavier atom, or fusion, binding two bodies of atoms together. The heavier an element, that is, the more protons and neutrons in its nucleus, the more unstable it is. Hence it is with great difficulty that scientists attempt to churn out new elements from large particle accelerators, by colliding and combining elements into new ones (Chheda, 2023). The story of physical matter is just one aspect in the search for what “everything” is made of. Dark matter and dark energy – so named because they do not interact with light – have been found to drive the expansion of the universe and the rotation speeds of galaxies. We know remarkably little about these substances, given that they make up around 95% of the total mass of the universe! Without a doubt, we have only just begun the journey to find out what makes up the universe around us. References Chheda, R. (2023, March 31). Can we add new elements to the periodic table? Science ABC. https://www.scienceabc.com/pure-sciences/can-we-add-new-elements-to-the-periodic-table.html Charley, S. (2012). How to make an element. PBS. https://www.pbs.org/wgbh/nova/insidenova/2012/01/how-to-make-an-element.html Free Animated Education. (2023, February 10). Perfecting the periodic table [Video]. YouTube. https://www.youtube.com/watch?v=7tbMGKGgCRA&ab_channel=FreeAnimatedEducation Jefferson Lab. (2012, November 20). The origin of the elements [Video]. YouTube. Ball, P. (2004). The elements: A very short introduction . Oxford University Press. Mee, N. (2020). Earth, air, fire, and water. In Oxford University Press eBooks (pp. 16–23). https://doi.org/10.1093/oso/9780198851950.003.0003 Rouvray, D. (2019). Dmitri Mendeleev. New Scientist. https://www.newscientist.com/people/dmitri-mendeleev Previous article Next article Elemental back to